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Microbiome-directed probiotic interventions have shown promise in preclinical and clinical studies, ameliorating UC through multiple mechanisms, including anti-inflammatory activity, epithelial barrier restoration, and remodeling of the intestinal microbiota

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Interleukin-1beta Induces ICAM-1 Expression Enhancing Leukocyte Adhesion in Human Rheumatoid Arthritis Synovial Fibroblasts: Involvement of ERK, JNK, AP-1, and NF-kappaB

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Despite these promising findings, DSIP remains largely experimental, with formal clinical approval, standardized dosing, and long-term safety data still lacking